Mohamed Eddouks
Professor at Moulay Ismail University
Title: Potent antihyperglycemic and hypoglycemic effect of Tamarix articulata Vahl. in normal and streptozotocin-induced diabetic rats
Biography
Biography: Mohamed Eddouks
Abstract
The purpose of this study was to investigate the effect of a single dose and daily oral administration for seven days of the aerial part aqueous extract (A.P.A.E) of Tamarix articulata Vahl. (T. articulata) at a dose of 5 mg/kg body weight on blood glucose levels in both normal and streptozotocin-induced diabetic rats (STZ). Single oral administration of T. articulata A.P.A.E reduced blood glucose levels 6 h after administration in normal rats and STZ diabetic rats (p<0.0001). Furthermore, blood glucose levels were decreased in both normal and STZ diabetic rats after seven days of treatment (p<0.0001). Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the oral glucose tolerance test, the aqueous extract of T. articulata (20 mg/kg) was shown to improve significantly the increase on blood glucose levels in normal treated rats (p<0.001) 90 min after glucose administration as compared to the control groups. Finally, histopathological analysis revealed the beneficial effect of T. articulata on pancreas and liver. In conclusion, this study demonstrates antihyperglycemic and hypoglycemic affects of T. articulata in severe diabetic state thus warrants further investigation on its major compounds with in depth mechanistic studies