Adeleh Khodabakhshi
Kerman University of Medical Sciences, Kerman, Iran
Title: Association between levels of Trimethylamine N-Oxide and cancer: A systematic review and meta-analysis
Biography
Biography: Adeleh Khodabakhshi
Abstract
Abstract: Cancer is the second-leading cause of death in the world. The effects of Trimethylamine-N-oxide (TAMO), a small amine oxide generated by gut microbial metabolism from choline, betaine, and carnitine, on cancer are inconsistent. Therefore, this systematic review and meta-analysis summarize the effects of TAMO on incidence of cancer. A systematic search was carried out in PubMed, Scopus, Web of Science, and Embase. Data were pooled using the random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). The pooled results of 16 studies, including 5930 participants, showed that the association between TMAO levels and incidence of cancer is insignificant (Odds Ratio: 0.97, 95% CI: (0.64, 1.46), p-value= 0.871). Subgroup analysis showed that urinary TMAO levels were negatively associated with cancer incidence; in contrast, a direct and positive association was observed between serum TMAO levels and its incidence. However, “gender” and also the “TMAO measuring method” were the potential source of heterogeneity. Meta-regression analysis did not reveal any significant association between duration of studies, age, female ratio, subjects-control, and subjects-case. The present study demonstrates that serum TAMO levels were insignificantly associated with incidence of cancer.